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OnGuard® 2 Closed System Transfer Device

The vapor is invisible, but the danger is real

The OnGuard 2 Closed System Transfer Device (CSTD) family of products is the only system tested with real hazardous drug solvents resulting in data-proven protection.1

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The danger of handling hazardous drugs is there—you just can't see it. OnGuard 2 CSTD provides safety and simplicity that's backed by science.

 

  • Tested and passed testing protocol based on the 2016 National Institute for Occupational Safety and Health (NIOSH) draft protocol for CSTDs, mechanically preventing the escape of hazardous drugs into the environment. 
  • Passed Microbial Ingress testing for up to seven days and 10 activations.
  • Supports compliance with USP <800> and internal safety protocols.
OnGuard Graphic - onguard-graphic-2-update
toxi-guard

Safety that's proven

OnGuard 2 is the only CSTD tested with real hazardous drug solvents for vapor containments.1
 

  • Compatible with known hazardous drugs to minimize exposure during preparation and injection.
  • Membrane-to-membrane connection is designed for a dry disconnect.1
  • Located in the vial adaptor, the ToxiGuard® Drug-Binding Matrix is a mechanical barrier that physically locks hazardous drug molecules and prevents the release of cytotoxic and other harmful drug vapors, aerosols and droplets into the environment during drug preparation and reconstitution. Additionally, it blocks airborne contaminants and particles from entering the drug or fluid path, ensuring a sterile environment.

Designed to offer simplicity to the entire health system 

The OnGuard 2 CSTD is designed to minimize the number of components. 

  • Fewer SKUs can reduce components and long-term costs. In fact, only four SKUs enable 98% of preparations and administrations.*
  • Fewer components means the OnGuard 2 CSTD can, on average, reduce storage space by 10%–15% and carrying costs by 5%.2

 

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Nurse with a mask and dressed in protective clothing looking at patient while holding OnGuard 2 CSTD.

Protecting healthcare workers at every connection point

The OnGuard® 2 CSTD delivers true closed-system protection from hazardous drug exposure—from compounding through administration. Built to safeguard clinicians while simplifying workflows, it combines safety, confidence and efficiency in every step.

What sets OnGuard 2 CSTD apart

Tested with real hazardous drug solvents for vapor containment, OnGuard 2 CSTD is the only CSTD scientifically proven to enhance safety when working with hazardous drugs.

The OnGuard 2 CSTD is designed to help protect staff without slowing down preparation or administration.

Some solutions are optimized for either compounding or administration. OnGuard 2 CSTD is built to support end-to-end workflows, enabling consistency across departments.

OnGuard 2 CSTD features an intuitive design intended to simplify onboarding and encourage user adoption.

OnGuard 2 CSTD is designed to integrate into existing workflows and setups, helping teams transition without major disruption.

For pharmacists who compound hazardous drugs, OnGuard 2 CSTD helps:

Minimize drug waste and cost of preparation

ToxiGuard® Technology ensures drug vapor containment and sterility—approved for up to seven days and 10 activations.3

Reduce limitations when preparing 

Compatible with known hazardous drugs.

Ensure a closed and safe connection— decreasing misuse of product

The audible “click” confirms the secure connection of the locking mechanism.

Cover all typical vial neck sizes

Suitable for 13 mm, 20 mm and 28 mm vials.

Eliminate extra components and reduce the need to store additional vial adapter sizes

One component for both 13 mm and 20 mm vials.

Limit drug waste

The maximum drug withdrawal is indicated by an arrow for minimizing residual volume within the vial.

Minimize the risk of exposure to hazardous drugs during administration

OnGuard 2 Closed System Device on an IV pole.

Bag Adaptor Spike Port

  • Effective, easy and quick swabbing.
  • Reduced repetitive strain injuries and easy grip of product.
  • Flexibility to work with any IV set.

Syringe Adaptor Lock

  • Connects to any of the other OnGuard 2 CTSD components with a simple click. For a secure connection that allows for the safe transfer of liquid from one container to another. 

Luer Lock Adaptor

  • Prevents exposure, keeping healthcare workers safe.
  • Less drug waste and reduced drug cost.
  • Creates a closed system.

Syringe Adaptor Lock

  • Can be attached to the distal end of the IV line. While a Luer lock adaptor is connected to the patient's port/Y-site. 

Syringe Adaptor Lock

  • Stays connected and locked. Unique patented locking system for Luer lock syringes.

Request more information

Fill out the form, and a B. Braun representative will contact you to discuss the OnGuard 2 CSTD.

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Additional OnGuard 2 CSTD Information

Learn more about the safety and simplicity offered by OnGuard 2 CSTD with these helpful downloads.

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References

  1. Levin G, Sessink PJ. Validation of chemotherapy drug vapor containment of an air cleaning closed-system drug transfer device. J. Oncol. Pharm. Pract. 2022;28(7):1508-1515. https://foi.oth/10.1177/10781552211030682.
  2. Jorgenson JA. Maximizing your CSTD return on investment. Pharmacy Practice News. 2017. https://www.pharmacypracticenews.com/Policy/Article/11-17/Maximizing-Your-CSTD-Return-on-Investment/45194. 
  3. OnGuard 2 Instructions for Use. 

*Based on average sales and in-use market in preparation - 20mm vial adaptor, syringe adaptor, bag adaptor, Luer Lock Adaptor